Summary
The paper investigates the molecular determinants of sex differences in sleep behavior, focusing on the differences in the transcriptome of the cerebral cortex of male and female mice after sleep deprivation.
Categories
Sleep and insomnia: The paper investigates the impact of sleep deprivation on the transcriptome of the cerebral cortex in male and female mice.
Cognitive function and memory: The study found that several genes related to cognitive function and memory, including Bdnf, Fosb and Fosl2, are differentially upregulated in males compared to females after sleep deprivation.
Hormone regulation: The paper identifies the androgen-receptor activating transcription factor EZH2 as the upstream regulatory element specifying sex differences in the sleep deprivation transcriptome.
Author(s)
T Shi, I Shah, Q Dang, L Taylor, A Jagannath
Publication Year
2023
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